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Gene: P2ry12 (purinergic receptor P2Y12) Rattus norvegicus
Symbol: P2ry12
Name: purinergic receptor P2Y12
Description: Exhibits G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; intracellular signal transduction; and positive regulation of cellular component biogenesis. Localizes to basal plasma membrane; caveola; and external side of plasma membrane. Colocalizes with mitochondrion. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane.
Type: protein-coding
Also known as: P2Y purinoceptor 12; P2y12; P2Y12 platelet ADP receptor; purinergic receptor P2Y, G-protein coupled 12; purinergic receptor P2Y, G-protein coupled, 12
Homo sapiens (human) : P2RY12 (purinergic receptor P2Y12)  HGNC  Alliance
Mus musculus (house mouse) : P2ry12 (purinergic receptor P2Y, G-protein coupled 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2ry12 (purinergic receptor P2Y12)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RY12 (purinergic receptor P2Y12)
Canis lupus familiaris (dog) : P2RY12 (purinergic receptor P2Y12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2ry12 (purinergic receptor P2Y12)
Sus scrofa (pig) : P2RY12 (purinergic receptor P2Y12)
Chlorocebus sabaeus (African green monkey) : P2RY12 (purinergic receptor P2Y12)
Heterocephalus glaber (naked mole-rat) : P2ry12 (purinergic receptor P2Y12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02149,440,807 - 149,482,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2149,441,598 - 149,444,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,873,062 - 168,914,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,611,035 - 148,613,985 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12148,560,997 - 148,563,948 (-)NCBI
Celera2137,906,910 - 137,909,860 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on P2ry12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621681
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.