Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Flt4 (Fms related receptor tyrosine kinase 4) Rattus norvegicus
Analyze
Symbol: Flt4
Name: Fms related receptor tyrosine kinase 4
Description: Exhibits growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in positive regulation of cell growth and vascular endothelial growth factor receptor signaling pathway. Predicted to localize to integral component of plasma membrane; nucleoplasm; and receptor complex. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4); PARTICIPATES IN vascular endothelial growth factor signaling pathway; altered vascular endothelial growth factor signaling pathway; altered vascular endothelial growth factor signaling pathway involving the main players; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FLT-4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LOC360235; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGFR-3; Vegfr3
Orthologs:
Homo sapiens (human) : FLT4 (fms related receptor tyrosine kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Flt4 (FMS-like tyrosine kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt4 (fms related receptor tyrosine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT4 (fms related receptor tyrosine kinase 4)
Canis lupus familiaris (dog) : FLT4 (fms related receptor tyrosine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt4 (fms related receptor tyrosine kinase 4)
Sus scrofa (pig) : FLT4 (fms related receptor tyrosine kinase 4)
Chlorocebus sabaeus (African green monkey) : FLT4 (fms related receptor tyrosine kinase 4)
Heterocephalus glaber (naked mole-rat) : Flt4 (fms related receptor tyrosine kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01035,078,782 - 35,120,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,078,726 - 35,121,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,850,707 - 34,892,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,071,002 - 35,112,006 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11035,072,050 - 35,113,055NCBI
Celera1033,270,535 - 33,311,432 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Flt4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621737
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-10
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.