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Gene: Gsr (glutathione-disulfide reductase) Rattus norvegicus
Symbol: Gsr
Name: glutathione-disulfide reductase
Description: Exhibits several functions, including coenzyme binding activity; glutathione binding activity; and glutathione-disulfide reductase activity. Involved in several processes, including response to iron(III) ion; response to ischemia; and response to vitamin A. Localizes to cytosol and mitochondrion. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including acute kidney failure (multiple); alcohol-induced mental disorder; hemorrhagic cystitis; myoglobinuria; and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-schisandrin B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glutathione reductase; glutathione reductase, mitochondrial; GR; GRase
Homo sapiens (human) : GSR (glutathione-disulfide reductase)  HGNC  Alliance
Mus musculus (house mouse) : Gsr (glutathione reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsr (glutathione-disulfide reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : GSR (glutathione-disulfide reductase)
Canis lupus familiaris (dog) : GSR (glutathione-disulfide reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsr (glutathione-disulfide reductase)
Sus scrofa (pig) : GSR (glutathione-disulfide reductase)
Chlorocebus sabaeus (African green monkey) : GSR (glutathione-disulfide reductase)
Heterocephalus glaber (naked mole-rat) : Gsr (glutathione-disulfide reductase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01662,197,617 - 62,239,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,197,617 - 62,241,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,859,601 - 61,901,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,255,562 - 62,298,458 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11662,255,636 - 62,298,530 (-)NCBI
Celera1656,518,556 - 56,560,956 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links