Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Vwf (von Willebrand factor) Rattus norvegicus
Symbol: Vwf
Name: von Willebrand factor
Description: Predicted to have several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including liver regeneration; platelet activation; and response to L-ascorbic acid. Localizes to collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; atrial fibrillation; end stage renal failure; essential thrombocythemia; and inherited blood coagulation disease (multiple). Orthologous to human VWF (von Willebrand factor); PARTICIPATES IN platelet aggregation pathway; cell-extracellular matrix signaling pathway; coagulation cascade pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: von Willebrand factor homolog
Homo sapiens (human) : VWF (von Willebrand factor)  HGNC  Alliance
Mus musculus (house mouse) : Vwf (Von Willebrand factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vwf (von Willebrand factor)
Pan paniscus (bonobo/pygmy chimpanzee) : VWF (von Willebrand factor)
Canis lupus familiaris (dog) : VWF (von Willebrand factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vwf (von Willebrand factor)
Sus scrofa (pig) : VWF (von Willebrand factor)
Chlorocebus sabaeus (African green monkey) : VWF (von Willebrand factor)
Heterocephalus glaber (naked mole-rat) : Vwf (von Willebrand factor)
more info ...
Allele / Splice: Vwfem2Mcwi   Vwfem3Mcwi  
Genetic Models: SS-Vwfem3Mcwi-/- SS-Vwfem2Mcwi-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Vwf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621759
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.