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Gene: Pola1 (DNA polymerase alpha 1, catalytic subunit) Rattus norvegicus
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Symbol: Pola1
Name: DNA polymerase alpha 1, catalytic subunit
Description: Exhibits DNA-directed DNA polymerase activity; double-stranded DNA binding activity; and nucleotide binding activity. Involved in DNA biosynthetic process and DNA replication. Localizes to the alpha DNA polymerase:primase complex. Predicted to colocalize with the chromatin. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit); PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; aphidicolin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha subunit I; polymerase (DNA directed), alpha 1; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit
Orthologs:
Homo sapiens (human) : POLA1 (DNA polymerase alpha 1, catalytic subunit)  HGNC  Alliance
Mus musculus (house mouse) : Pola1 (polymerase (DNA directed), alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Canis lupus familiaris (dog) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Sus scrofa (pig) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X62,382,604 - 62,698,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X63,279,367 - 63,291,732 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X62,976,409 - 63,270,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X80,650,454 - 80,965,833 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X80,724,688 - 81,039,135 (-)NCBI
CeleraX58,474,102 - 58,787,051 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pola1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621816
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.