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Gene: Slc6a2 (solute carrier family 6 member 2) Rattus norvegicus
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Symbol: Slc6a2
Name: solute carrier family 6 member 2
Description: Exhibits alpha-tubulin binding activity; beta-tubulin binding activity; and norepinephrine:sodium symporter activity. Involved in norepinephrine transport and response to drug. Localizes to several cellular components, including the cell surface; membrane raft; and plasma membrane. Biomarker of mental depression. Human ortholog(s) of this gene implicated in hypertension and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (R)-noradrenaline; (S)-amphetamine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: NaCl-dependent norepinephrine transporter; Net; neurotransmitter transporter, noradrenal; norepinephrine transporter; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; solute carrier family 6 (neurotransmitter transporter,noradrenalin), member 2; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
Orthologs:
Homo sapiens (human) : SLC6A2 (solute carrier family 6 member 2)  HGNC  Alliance
Mus musculus (house mouse) : Slc6a2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a2 (solute carrier family 6 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A2 (solute carrier family 6 member 2)
Canis lupus familiaris (dog) : SLC6A2 (solute carrier family 6 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a2 (solute carrier family 6 member 2)
Sus scrofa (pig) : SLC6A2 (solute carrier family 6 member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01915,391,682 - 15,431,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01926,487,820 - 26,527,769 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,098,281 - 15,139,898 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11915,103,106 - 15,144,724 (-)NCBI
Celera1913,934,272 - 13,973,888 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc6a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621822
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.