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Gene: Pfn1 (profilin 1) Rattus norvegicus
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Symbol: Pfn1
Name: profilin 1
Description: Exhibits phosphatidylinositol-4,5-bisphosphate binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of nucleobase-containing compound metabolic process; positive regulation of stress fiber assembly; and positive regulation of viral transcription. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1); INTERACTS WITH (S)-nicotine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: profilin; profilin I; profilin-1
Orthologs:
Homo sapiens (human) : PFN1 (profilin 1)  HGNC  Alliance
Mus musculus (house mouse) : Pfn1 (profilin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pfn1 (profilin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PFN1 (profilin 1)
Canis lupus familiaris (dog) : PFN1 (profilin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pfn1 (profilin 1)
Sus scrofa (pig) : PFN1 (profilin 1)
Chlorocebus sabaeus (African green monkey) : PFN1 (profilin 1)
Heterocephalus glaber (naked mole-rat) : Pfn1 (profilin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01057,273,003 - 57,275,708 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,273,005 - 57,275,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,018,597 - 57,021,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,531,661 - 57,534,366 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,545,285 - 57,547,989 (-)NCBI
Celera1054,510,819 - 54,513,524 (-)NCBICelera
Cytogenetic Map10q24NCBI
RH 3.4 Map9783.99RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Pfn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621825
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.