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Gene: Cyb5r4 (cytochrome b5 reductase 4) Rattus norvegicus
Symbol: Cyb5r4
Name: cytochrome b5 reductase 4
Description: Exhibits NADPH-hemoprotein reductase activity; flavin adenine dinucleotide binding activity; and heme binding activity. Involved in NADP metabolic process. Predicted to localize to the endoplasmic reticulum and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4); INTERACTS WITH bisphenol A; finasteride; flavonoids.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: b5&b5R; b5+b5R; cb5/cb5R; flavohemoprotein b5+b5R; flavohemoprotein b5/b5R; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; NADPH cytochrome B5 oxidoreductase; Ncb5or
Homo sapiens (human) : CYB5R4 (cytochrome b5 reductase 4)  HGNC  Alliance
Mus musculus (house mouse) : Cyb5r4 (cytochrome b5 reductase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102015388 (cytochrome b5 reductase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100977566 (cytochrome b5 reductase 4)
Canis lupus familiaris (dog) : CYB5R4 (cytochrome b5 reductase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101972377 (cytochrome b5 reductase 4)
Sus scrofa (pig) : LOC100622980 (cytochrome b5 reductase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0894,693,273 - 94,757,989 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0894,201,509 - 94,266,046 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4892,278,453 - 92,343,490 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1892,297,907 - 92,362,944 (+)NCBI
Celera887,566,998 - 87,631,697 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cyb5r4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621834
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.