Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Atf4 (activating transcription factor 4) Rattus norvegicus
Symbol: Atf4
Name: activating transcription factor 4
Description: Exhibits protein C-terminus binding activity and transcription factor binding activity. Predicted to contribute to transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; gamma-aminobutyric acid signaling pathway; and response to manganese-induced endoplasmic reticulum stress. Localizes to cytoplasm; dendrite membrane; and nucleus. Predicted to colocalize with centrosome. Biomarker of borna disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Endoplasmic Reticulum-associated degradation pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; cyclic AMP-dependent transcription factor ATF-4; rATF-4
Homo sapiens (human) : ATF4 (activating transcription factor 4)  HGNC  Alliance
Mus musculus (house mouse) : Atf4 (activating transcription factor 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atf4 (activating transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ATF4 (activating transcription factor 4)
Canis lupus familiaris (dog) : ATF4 (activating transcription factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atf4 (activating transcription factor 4)
Sus scrofa (pig) : ATF4 (activating transcription factor 4)
Chlorocebus sabaeus (African green monkey) : ATF4 (activating transcription factor 4)
Heterocephalus glaber (naked mole-rat) : Atf4 (activating transcription factor 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Atf4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621863
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.