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Gene: Rapgef3 (Rap guanine nucleotide exchange factor 3) Rattus norvegicus
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Symbol: Rapgef3
Name: Rap guanine nucleotide exchange factor 3
Description: Exhibits cAMP binding activity and ion channel binding activity. Involved in several processes, including animal organ development; positive regulation of cation transmembrane transport; and positive regulation of nitrogen compound metabolic process. Localizes to several cellular components, including the actin-based cell projection; basolateral part of cell; and distal axon. Colocalizes with the cortical actin cytoskeleton and plasma membrane. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3); PARTICIPATES IN adenosine signaling pathway; long term potentiation; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI); Epac; epac 1; exchange factor directly activated by cAMP 1; exchange protein directly activated by cAMP 1; MGC124613; Rap guanine nucleotide exchange factor (GEF) 3
Orthologs:
Homo sapiens (human) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)  HGNC  Alliance
Mus musculus (house mouse) : Rapgef3 (Rap guanine nucleotide exchange factor (GEF) 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef3 (Rap guanine nucleotide exchange factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)
Canis lupus familiaris (dog) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef3 (Rap guanine nucleotide exchange factor 3)
Sus scrofa (pig) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07139,232,263 - 139,254,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07139,423,916 - 139,445,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,452,945 - 136,474,659 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17136,529,382 - 136,551,096 (-)NCBI
Celera7125,367,430 - 125,389,118 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Rapgef3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621869
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.