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Gene: Rapgef4 (Rap guanine nucleotide exchange factor 4) Rattus norvegicus
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Symbol: Rapgef4
Name: Rap guanine nucleotide exchange factor 4
Description: Exhibits cAMP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including nervous system development; positive regulation of neuronal action potential; and response to benzene. Localizes to several cellular components, including basolateral plasma membrane; brush border; and distal axon. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CAMPS; Cgef2; epac 2; Epac2; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; Rap guanine nucleotide exchange factor (GEF) 4
Orthologs:
Homo sapiens (human) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)  HGNC  Alliance
Mus musculus (house mouse) : Rapgef4 (Rap guanine nucleotide exchange factor (GEF) 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Canis lupus familiaris (dog) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
Sus scrofa (pig) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Chlorocebus sabaeus (African green monkey) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Heterocephalus glaber (naked mole-rat) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
more info ...
Allele / Splice: Rapgef4Tn(sb-T2/Bart3)2.314Mcwi  
Genetic Models: F344-Rapgef4Tn(sb-T2/Bart3)2.314Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0358,632,338 - 58,925,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,632,476 - 58,924,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0365,122,705 - 65,409,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4354,396,312 - 54,717,148 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1354,578,917 - 54,613,517 (+)NCBI
Celera356,352,070 - 56,643,335 (+)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Rapgef4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621886
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.