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Gene: Isl1 (ISL1 transcription factor, LIM/homeodomain) Mus musculus
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Symbol: Isl1
Name: ISL1 transcription factor, LIM/homeodomain
Description: Exhibits promoter-specific chromatin binding activity; sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cytokine production. Localizes to nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: insulin gene enhancer protein ISL-1; insulin related protein; Islet 1; islet-1; Lim-homeodomain protein Islet1
Orthologs:
Homo sapiens (human) : ISL1 (ISL LIM homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Isl1 (ISL LIM homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isl1 (ISL LIM homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ISL1 (ISL LIM homeobox 1)
Canis lupus familiaris (dog) : ISL1 (ISL LIM homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isl1 (ISL LIM homeobox 1)
Sus scrofa (pig) : ISL1 (ISL LIM homeobox 1)
Chlorocebus sabaeus (African green monkey) : ISL1 (ISL LIM homeobox 1)
Heterocephalus glaber (naked mole-rat) : Isl1 (ISL LIM homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl13116,298,281 - 116,309,689 (-)EnsemblGRCm38mm10GRCm38
GRCm3813116,298,270 - 116,309,688 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3713117,088,478 - 117,099,896 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613117,418,963 - 117,430,370 (-)NCBImm8
Celera13120,696,034 - 120,707,388 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Isl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62250
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.