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Gene: Isl1 (ISL1 transcription factor, LIM/homeodomain) Mus musculus
Symbol: Isl1
Name: ISL1 transcription factor, LIM/homeodomain
Description: Exhibits promoter-specific chromatin binding activity; sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cytokine production. Localizes to nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: insulin gene enhancer protein ISL-1; insulin related protein; Islet 1; islet-1; Lim-homeodomain protein Islet1
Homo sapiens (human) : ISL1 (ISL LIM homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Isl1 (ISL LIM homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isl1 (ISL LIM homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ISL1 (ISL LIM homeobox 1)
Canis lupus familiaris (dog) : ISL1 (ISL LIM homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isl1 (ISL LIM homeobox 1)
Sus scrofa (pig) : ISL1 (ISL LIM homeobox 1)
Chlorocebus sabaeus (African green monkey) : ISL1 (ISL LIM homeobox 1)
Heterocephalus glaber (naked mole-rat) : Isl1 (ISL LIM homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl13116,298,281 - 116,309,689 (-)EnsemblGRCm38mm10GRCm38
GRCm3813116,298,270 - 116,309,688 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3713117,088,478 - 117,099,896 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613117,418,963 - 117,430,370 (-)NCBImm8
Celera13120,696,034 - 120,707,388 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Isl1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62250
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.