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Gene: Ptpn1 (protein tyrosine phosphatase, non-receptor type 1) Mus musculus
Symbol: Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Description: Predicted to have several functions, including protein phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to early endosome and sorting endosome. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in central nervous system; midbrain; and superior colliculus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; protein-tyrosine phosphatase HA2; PTP-1B; PTP-HA2; PTP1B; tyrosine-protein phosphatase non-receptor type 1
Homo sapiens (human) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptpn1 (protein tyrosine phosphatase, non-receptor type 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Canis lupus familiaris (dog) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
Sus scrofa (pig) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Chlorocebus sabaeus (African green monkey) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Heterocephalus glaber (naked mole-rat) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2167,932,057 - 167,979,385 (+)EnsemblGRCm38mm10GRCm38
GRCm382167,930,750 - 167,979,385 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372167,757,827 - 167,804,885 (+)NCBIGRCm37mm9NCBIm37
MGSCv362167,623,579 - 167,668,124 (+)NCBImm8
Celera2173,874,374 - 173,921,508 (+)NCBICelera
Cytogenetic Map2H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptpn1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62258
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.