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Gene: Ptpn1 (protein tyrosine phosphatase, non-receptor type 1) Mus musculus
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Symbol: Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Description: Predicted to have several functions, including protein phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to early endosome and sorting endosome. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in central nervous system; midbrain; and superior colliculus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; protein-tyrosine phosphatase HA2; PTP-1B; PTP-HA2; PTP1B; tyrosine-protein phosphatase non-receptor type 1
Orthologs:
Homo sapiens (human) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptpn1 (protein tyrosine phosphatase, non-receptor type 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Canis lupus familiaris (dog) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
Sus scrofa (pig) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Chlorocebus sabaeus (African green monkey) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Heterocephalus glaber (naked mole-rat) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl2167,932,057 - 167,979,385 (+)EnsemblGRCm38mm10GRCm38
GRCm382167,930,750 - 167,979,385 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372167,757,827 - 167,804,885 (+)NCBIGRCm37mm9NCBIm37
MGSCv362167,623,579 - 167,668,124 (+)NCBImm8
Celera2173,874,374 - 173,921,508 (+)NCBICelera
Cytogenetic Map2H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ptpn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62258
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-05-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.