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Gene: Pten (phosphatase and tensin homolog) Mus musculus
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Symbol: Pten
Name: phosphatase and tensin homolog
Description: Exhibits phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein kinase binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of apoptotic process. Localizes to several cellular components, including the Schmidt-Lanterman incisure; myelin sheath adaxonal region; and neuron projection. Used to study several diseases, including Bannayan-Riley-Ruvalcaba syndrome; Cowden syndrome; endocrine gland cancer (multiple); intestinal pseudo-obstruction; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; breast cancer (multiple); lung non-small cell carcinoma; macrocephaly-autism syndrome; and nervous system cancer (multiple). Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Orthologous to human PTEN (phosphatase and tensin homolog).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MGC183880; mitochondrial PTENalpha; MMAC1; mutated in multiple advanced cancers 1; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTENbeta; RIKEN cDNA B430203M17 gene; TEP1
Orthologs:
Homo sapiens (human) : PTEN (phosphatase and tensin homolog)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pten (phosphatase and tensin homolog)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pten (phosphatase and tensin homolog)
Pan paniscus (bonobo/pygmy chimpanzee) : PTEN (phosphatase and tensin homolog)
Canis lupus familiaris (dog) : PTEN (phosphatase and tensin homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pten (phosphatase and tensin homolog)
Sus scrofa (pig) : PTEN (phosphatase and tensin homolog)
Chlorocebus sabaeus (African green monkey) : PTEN (phosphatase and tensin homolog)
Heterocephalus glaber (naked mole-rat) : Pten (phosphatase and tensin homolog)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1932,757,497 - 32,826,160 (+)Ensembl
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIGRCm37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBImm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model