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Gene: Ptpro (protein tyrosine phosphatase, receptor type, O) Mus musculus
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Symbol: Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Description: Exhibits Wnt-protein binding activity; protein homodimerization activity; and protein tyrosine phosphatase activity. Involved in several processes, including peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; plasma membrane bounded cell projection organization; and slit diaphragm assembly. Localizes to several cellular components, including GABA-ergic synapse; integral component of postsynaptic density membrane; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D28; GLEPP1; glomerular epithelial protein 1; protein tyrosine phosphatase U2; protein tyrosine phosphatase, non-receptor type 15; PTPase U2; PTPBK; Ptpn15; PTPoc; PTPphi; PTPROt; PTPU2; R-PTP-O; receptor protein tyrosine phosphatase RO; receptor-type tyrosine-protein phosphatase O
Orthologs:
Homo sapiens (human) : PTPRO (protein tyrosine phosphatase receptor type O)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptpro (protein tyrosine phosphatase, receptor type, O)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpro (protein tyrosine phosphatase receptor type O)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRO (protein tyrosine phosphatase receptor type O)
Canis lupus familiaris (dog) : PTPRO (protein tyrosine phosphatase receptor type O)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpro (protein tyrosine phosphatase receptor type O)
Sus scrofa (pig) : PTPRO (protein tyrosine phosphatase receptor type O)
Chlorocebus sabaeus (African green monkey) : PTPRO (protein tyrosine phosphatase receptor type O)
Heterocephalus glaber (naked mole-rat) : Ptpro (protein tyrosine phosphatase receptor type O)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl6137,252,319 - 137,463,233 (+)EnsemblGRCm38mm10GRCm38
GRCm386137,252,299 - 137,464,634 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376137,200,820 - 137,413,155 (+)NCBIGRCm37mm9NCBIm37
MGSCv366137,216,661 - 137,427,429 (+)NCBImm8
Celera6140,313,708 - 140,529,181 (+)NCBICelera
Cytogenetic Map6G1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Ptpro
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62360
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.