Gene: Ddit3 (DNA-damage inducible transcript 3) Rattus norvegicus
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Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Description: Exhibits DNA-binding transcription factor activity and protein heterodimerization activity; contributes to sequence-specific DNA binding activity; involved in several processes, including aging, animal organ development, and regulation of cellular biosynthetic process; localizes to the CHOP-C/EBP complex and cytoplasm; predicted to colocalize with the transcription factor AP-1 complex; biomarker of several diseases, including acute kidney failure, brain ischemia, chronic obstructive pulmonary disease, galactosemia, and nephrosis; orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C/EBP homologous protein; C/EBP zeta; c/EBP-homologous protein; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; Chop10; DDIT-3; DNA damage-inducible transcript 3; Gadd153; growth arrest and DNA-damage-inducible protein GADD153; MGC124604; RM4
Orthologs:
Homo sapiens (human) : DDIT3 (DNA damage inducible transcript 3)  HGNC  Alliance
Mus musculus (house mouse) : Ddit3 (DNA-damage inducible transcript 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit3 (DNA damage inducible transcript 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT3 (DNA damage inducible transcript 3)
Canis lupus familiaris (dog) : DDIT3 (DNA damage inducible transcript 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit3 (DNA damage inducible transcript 3)
Sus scrofa (pig) : DDIT3 (DNA damage inducible transcript 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)