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Gene: Cyp3a23/3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1) Rattus norvegicus
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Symbol: Cyp3a23/3a1
Name: cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1
Description: Exhibits demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in several processes, including oxidative demethylation; response to cadmium ion; and response to glucocorticoid. Localizes to the endoplasmic reticulum membrane and intracellular membrane-bounded organelle. Biomarker of cholestasis and mental depression. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; essential hypertension; precursor B lymphoblastic lymphoma/leukemia; and precursor lymphoblastic lymphoma/leukemia. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trichlorobenzene; 1,2-dichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cDEX; CYP; Cyp3a1; CYP3A23; Cyp3a3; CYPIIIA1; cytochrome P-450PCN (PNCN inducible); cytochrome P450 3A1; cytochrome P450, family 3, subfamily a, polypeptide 1; cytochrome P450, subfamily 3A, polypeptide 3; Cytochrome P450, subfamily IIIA, polypeptide 3; cytochrome P450-PCN1; cytochrome P450/6 beta B; MGC108757; P450 IIIA; P450-PCN1; RL33
Orthologs:
No known orthologs. homologs ...
Allele / Splice: Cyp3a23/3a1em1Myliu  
Genetic Models: SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01211,053,888 - 11,082,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)Ensembl
Rnor_5.01213,145,742 - 13,174,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,567,120 - 9,595,974 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1129,596,712 - 9,625,890 (-)NCBI
Celera1211,063,015 - 11,090,937 (-)NCBICelera
Cytogenetic Map12p11NCBI
RH 3.4 Map12117.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp3a23/3a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628626
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.