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Gene: Ptger4 (prostaglandin E receptor 4) Rattus norvegicus
Symbol: Ptger4
Name: prostaglandin E receptor 4
Description: Exhibits prostaglandin E receptor activity. Involved in several processes, including MAPK cascade; regulation of circadian sleep/wake cycle, sleep; and regulation of secretion. Localizes to several cellular components, including neuron projection terminus; neuronal cell body; and nuclear membrane. Used to study acute kidney failure; cystitis; end stage renal disease; myocarditis; and osteoporosis. Biomarker of retinal ischemia and transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4); INTERACTS WITH 17beta-estradiol; 2,3-bis(4-hydroxyphenyl)propionitrile; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
Also known as: EP4; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; prostaglandin E2 receptor type 4; prostanoid EP4 receptor; Ptger; Ptgerep4
Homo sapiens (human) : PTGER4 (prostaglandin E receptor 4)  HGNC  Alliance
Mus musculus (house mouse) : Ptger4 (prostaglandin E receptor 4 (subtype EP4))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptger4 (prostaglandin E receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGER4 (prostaglandin E receptor 4)
Canis lupus familiaris (dog) : PTGER4 (prostaglandin E receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptger4 (prostaglandin E receptor 4)
Sus scrofa (pig) : PTGER4 (prostaglandin E receptor 4)
Chlorocebus sabaeus (African green monkey) : PTGER4 (prostaglandin E receptor 4)
Heterocephalus glaber (naked mole-rat) : Ptger4 (prostaglandin E receptor 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0254,951,625 - 54,966,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,952,821 - 54,963,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,974,390 - 73,987,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,423,280 - 54,433,907 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,351,507 - 54,362,753 (-)NCBI
Celera249,982,896 - 49,993,523 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptger4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628641
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.