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Gene: Gm2a (GM2 ganglioside activator) Rattus norvegicus
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Symbol: Gm2a
Name: GM2 ganglioside activator
Description: Exhibits lipid transporter activity and phospholipase activator activity. Contributes to beta-N-acetylgalactosaminidase activity. Involved in ganglioside metabolic process; lipid transport; and positive regulation of hydrolase activity. Localizes to several cellular components, including the apical plasma membrane; basolateral plasma membrane; and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in GM2 gangliosidosis and GM2 gangliosidosis, AB variant. Orthologous to human GM2A (GM2 ganglioside activator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ganglioside GM2 activator; GM2 ganglioside activator protein
Orthologs:
Homo sapiens (human) : GM2A (GM2 ganglioside activator)  HGNC  Alliance
Mus musculus (house mouse) : Gm2a (GM2 ganglioside activator protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gm2a (GM2 ganglioside activator)
Pan paniscus (bonobo/pygmy chimpanzee) : GM2A (GM2 ganglioside activator)
Canis lupus familiaris (dog) : GM2A (GM2 ganglioside activator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gm2a (GM2 ganglioside activator)
Sus scrofa (pig) : GM2A (GM2 ganglioside activator)
Chlorocebus sabaeus (green monkey) : GM2A (GM2 ganglioside activator)
Heterocephalus glaber (naked mole-rat) : Gm2a (GM2 ganglioside activator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01040,438,394 - 40,450,927 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,438,356 - 40,450,930 (+)Ensembl
Rnor_5.01040,277,005 - 40,289,541 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,502,175 - 40,514,708 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11040,515,797 - 40,528,331 (+)NCBI
Celera1038,556,830 - 38,569,363 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Gm2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628651
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.