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Gene: Gnao1 (G protein subunit alpha o1) Rattus norvegicus
Symbol: Gnao1
Name: G protein subunit alpha o1
CRRD ID: 628732
Description: Exhibits several functions, including G protein-coupled receptor binding activity; GTP binding activity; and GTPase activating protein binding activity. Involved in several processes, including nervous system development; positive regulation of GTPase activity; and response to morphine. Localizes to several cellular components, including membrane; myelin sheath; and neuron projection. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 17. Orthologous to human GNAO1 (G protein subunit alpha o1); PARTICIPATES IN G protein mediated signaling pathway; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
Also known as: Gnao; GTP-binding protein; GTP-binding protein alpha o; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O; guanine nucleotide binding protein, alpha O polypeptide 1; guanine nucleotide-binding protein G(o) subunit alpha; RATBPGTPC
Homo sapiens (human) : GNAO1 (G protein subunit alpha o1)  HGNC  Alliance
Mus musculus (house mouse) : Gnao1 (guanine nucleotide binding protein, alpha O)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnao1 (G protein subunit alpha o1)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAO1 (G protein subunit alpha o1)
Canis lupus familiaris (dog) : GNAO1 (G protein subunit alpha o1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnao1 (G protein subunit alpha o1)
Sus scrofa (pig) : GNAO1 (G protein subunit alpha o1)
Chlorocebus sabaeus (African green monkey) : GNAO1 (G protein subunit alpha o1)
Heterocephalus glaber (naked mole-rat) : Gnao1 (G protein subunit alpha o1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01911,513,201 - 11,669,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,513,201 - 11,669,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,487,578 - 11,643,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,472,083 - 11,623,600 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11911,476,908 - 11,628,426 (-)NCBI
Celera1910,919,521 - 11,074,052 (-)NCBICelera
Cytogenetic Map19p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gnao1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628732
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.