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Gene: Lgi1 (leucine-rich, glioma inactivated 1) Rattus norvegicus
Symbol: Lgi1
Name: leucine-rich, glioma inactivated 1
Description: Predicted to have signaling receptor binding activity. Involved in positive regulation of synaptic transmission and protein homooligomerization. Localizes to the extracellular space and synapse. Used to study epilepsy. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 1. Orthologous to human LGI1 (leucine rich glioma inactivated 1); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
Also known as: leucine-rich glioma-inactivated protein 1; leucine-rich glioma-inactivated protein 1-like; leucine-rich repeat LGI family, member 1; MGC105310
Homo sapiens (human) : LGI1 (leucine rich glioma inactivated 1)  HGNC  Alliance
Mus musculus (house mouse) : Lgi1 (leucine-rich repeat LGI family, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lgi1 (leucine rich glioma inactivated 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LGI1 (leucine rich glioma inactivated 1)
Canis lupus familiaris (dog) : LGI1 (leucine rich glioma inactivated 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lgi1 (leucine rich glioma inactivated 1)
Sus scrofa (pig) : LGI1 (leucine rich glioma inactivated 1)
more info ...
Allele / Splice: Lgi1m1Kyo  
Genetic Models: F344-Lgi1m1Kyo
Is Marker For: Strains:   F344.NER-(D1Mgh6-D1Rat73)(D5Mgh4-D5Rat36)Lgi1m1/Kyo   F344-Lgi1m1Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01256,955,944 - 256,996,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01264,436,441 - 264,477,332 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,593,236 - 242,634,141 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,809,453 - 242,810,274 (+)NCBI
Celera1233,136,652 - 233,177,516 (+)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Lgi1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628742
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.