Gene: Shank2 (SH3 and multiple ankyrin repeat domains 2) Rattus norvegicus
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Symbol: Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Description: Exhibits SH3 domain binding activity and protein C-terminus binding activity; involved in brain development, regulation of synapse organization, and response to nutrient; localizes to several cellular components, including the apical plasma membrane, glutamatergic synapse, and plasma membrane bounded cell projection part; predicted to colocalize with the ionotropic glutamate receptor complex, neurofilament, and postsynaptic membrane; orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH ammonium chloride; androgen antagonist; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cortactin-binding protein 1; CortBP1; GKAP/SAPAP-interacting protein; proline rich synapse associated protein 1; proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; Spank-3
Orthologs:
Homo sapiens (human) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)  HGNC  Alliance
Mus musculus (house mouse) : Shank2 (SH3 and multiple ankyrin repeat domains 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank2 (SH3 and multiple ankyrin repeat domains 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)
Canis lupus familiaris (dog) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101967789 (SH3 and multiple ankyrin repeat domains protein 2)
Sus scrofa (pig) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01217,149,156 - 217,593,950 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,118,530 - 222,150,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01224,028,791 - 224,450,737 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,399,856 - 204,855,474 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11204,553,308 - 205,005,561 (+)NCBI
Celera1196,732,183 - 197,149,084 (+)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Shank2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628772
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.