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Gene: Mfn2 (mitofusin 2) Rattus norvegicus
Symbol: Mfn2
Name: mitofusin 2
Description: Exhibits several functions, including GTP binding activity; identical protein binding activity; and proteoglycan binding activity. Involved in several processes, including mitochondrion organization; negative regulation of cell death; and regulation of cell development. Localizes to cytosol and intrinsic component of mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); fatty liver disease (multiple); obesity; prediabetes syndrome; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,4-dinitrotoluene; 2-tert-butylhydroquinone.
Type: protein-coding
Also known as: HSG; hypertension-related protein; mitochondrial transmembrane GTPase FZO1A; mitofusin-2; transmembrane GTPase MFN2
Homo sapiens (human) : MFN2 (mitofusin 2)  HGNC  Alliance
Mus musculus (house mouse) : Mfn2 (mitofusin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mfn2 (mitofusin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MFN2 (mitofusin 2)
Canis lupus familiaris (dog) : MFN2 (mitofusin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mfn2 (mitofusin 2)
Sus scrofa (pig) : MFN2 (mitofusin 2)
Chlorocebus sabaeus (African green monkey) : MFN2 (mitofusin 2)
Heterocephalus glaber (naked mole-rat) : Mfn2 (mitofusin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: GeneIDs: 64476 and 100911485 are annotated independently on Rnor_6.0 but may be redundant loci. [09 Feb 2015]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Celera5156,587,853 - 156,617,496 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Mfn2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628843
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.