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Gene: Agap2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2) Rattus norvegicus
Symbol: Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
CRRD ID: 628844
Description: Exhibits protein kinase activator activity and protein kinase binding activity. Involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and positive regulation of phosphatidylinositol 3-kinase signaling. Localizes to nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AGAP-2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin, gamma 1; centaurin-gamma-1; Centg1; cnt-g1; nuclear GTPase PIKE; phosphatidylinositol 3-kinase enhancer; phosphatidylinositol-3-kinase enhancer; Pike
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0770,360,199 - 70,377,422 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,364,813 - 70,377,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,538,136 - 70,555,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,031,300 - 67,043,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,052,029 - 67,059,503 (+)NCBI
Celera760,045,054 - 60,057,649 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Agap2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 628844
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.