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Gene: Cdk5r1 (cyclin-dependent kinase 5 regulatory subunit 1) Rattus norvegicus
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Symbol: Cdk5r1
Name: cyclin-dependent kinase 5 regulatory subunit 1
Description: Exhibits several functions, including cadherin binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and ephrin receptor binding activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; nervous system development; and positive regulation of neuron apoptotic process. Localizes to several cellular components, including growth cone; postsynaptic density; and protein kinase 5 complex. Biomarker of hypothyroidism; mental depression; and trigeminal neuralgia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1); PARTICIPATES IN Reelin signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (S)-amphetamine; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CDK5 activator 1; Cdk5r; cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5, regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); p23; p35; tau protein kinase II 23 kDa subunit; TPKII regulatory subunit
Orthologs:
Homo sapiens (human) : CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Cdk5r1 (cyclin-dependent kinase 5, regulatory subunit 1 (p35))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk5r1 (cyclin dependent kinase 5 regulatory subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)
Canis lupus familiaris (dog) : CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk5r1 (cyclin dependent kinase 5 regulatory subunit 1)
Sus scrofa (pig) : CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)
Chlorocebus sabaeus (African green monkey) : CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1)
Heterocephalus glaber (naked mole-rat) : Cdk5r1 (cyclin dependent kinase 5 regulatory subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01067,862,054 - 67,863,255 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,862,054 - 67,863,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01067,515,764 - 67,516,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41068,715,844 - 68,717,045 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11068,729,476 - 68,730,668 (+)NCBI
Celera1064,442,587 - 64,443,788 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cdk5r1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 629472
Created: 2003-04-06
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.