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Gene: Tph2 (tryptophan hydroxylase 2) Rattus norvegicus
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Symbol: Tph2
Name: tryptophan hydroxylase 2
Description: Predicted to have tryptophan 5-monooxygenase activity. Involved in several processes, including cellular response to lithium ion; response to calcium ion; and response to estrogen. Predicted to localize to the neuron projection. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH 17beta-estradiol; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: neuronal tryptophan hydroxylase; Ntph; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2
Orthologs:
Homo sapiens (human) : TPH2 (tryptophan hydroxylase 2)  HGNC  Alliance
Mus musculus (house mouse) : Tph2 (tryptophan hydroxylase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tph2 (tryptophan hydroxylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TPH2 (tryptophan hydroxylase 2)
Canis lupus familiaris (dog) : TPH2 (tryptophan hydroxylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tph2 (tryptophan hydroxylase 2)
Sus scrofa (pig) : TPH2 (tryptophan hydroxylase 2)
more info ...
Allele / Splice: Tph2em2Mcwi   Tph2em3Mcwi  
Genetic Models: DA-Tph2em2Mcwi DA-Tph2em3Mcwi DA-Tph2em3Mcwi+/+ DA-Tph2em2Mcwi-/- DA-Tph2em3Mcwi-/- DA-Tph2em2Mcwi+/- DA-Tph2em3Mcwi+/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0758,042,279 - 58,149,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0758,053,268 - 58,157,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,321,033 - 54,430,706 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1754,341,665 - 54,451,339 (-)NCBI
Celera747,478,282 - 47,582,240 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tph2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 631332
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.