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Gene: Cyp4a3 (cytochrome P450, family 4, subfamily a, polypeptide 3) Rattus norvegicus
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Symbol: Cyp4a3
Name: cytochrome P450, family 4, subfamily a, polypeptide 3
Description: Exhibits alkane 1-monooxygenase activity and arachidonic acid monooxygenase activity. Involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Localizes to the intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; linoleic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH (2-trans,6-trans)-farnesol; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp4a14; CYPIVA14; CYPIVA3; cytochrome P450 4A14; cytochrome P450 4A3; cytochrome P450, family 4, subfamily a, polypeptide 14; cytochrome P450-LA-omega 3; long-chain fatty acid omega-monooxygenase; P450-LA-omega 3
Orthologs:
No known orthologs. homologs ...
Allele / Splice: Cyp4a3em3Mcwi  
Genetic Models: SS-Chr 5BN-Cyp4a3em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05134,468,666 - 134,484,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05138,258,628 - 138,274,813 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,876,140 - 135,893,753 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15135,881,365 - 135,898,979 (-)NCBI
Celera5127,635,617 - 127,653,155 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp4a3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 631356
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.