Gene: Egln1 (egl-9 family hypoxia-inducible factor 1) Rattus norvegicus
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Symbol: Egln1
Name: egl-9 family hypoxia-inducible factor 1
Description: Exhibits enzyme binding activity and peptidyl-proline dioxygenase activity; involved in several processes, including negative regulation of CAMKK-AMPK signaling cascade, negative regulation of DNA-binding transcription factor activity, and positive regulation of cell death; localizes to the cytosol; used to study hypertension; biomarker of acute kidney failure and myocardial infarction; orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; astemizole.
Type: protein-coding
RefSeq Status: MODEL
Also known as: egl nine homolog 1; EGL nine homolog 1 (C. elegans); HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; hypoxia-inducible factor prolyl hydroxylase 2; LOW QUALITY PROTEIN: egl nine homolog 1; PHD-2; PHD2; prolyl hydroxylase domain-containing protein 2
Orthologs:
Homo sapiens (human) : EGLN1 (egl-9 family hypoxia inducible factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Egln1 (egl-9 family hypoxia-inducible factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln1 (egl-9 family hypoxia inducible factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Canis lupus familiaris (dog) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln1 (egl-9 family hypoxia inducible factor 1)
Sus scrofa (pig) : EGLN1 (egl-9 family hypoxia inducible factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01957,660,194 - 57,701,158 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01968,373,433 - 68,412,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,080,670 - 55,118,226 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11955,086,125 - 55,122,813 (-)NCBI
Celera1952,235,066 - 52,273,829 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Egln1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 631375
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.