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Gene: Slc22a8 (solute carrier family 22 member 8) Rattus norvegicus
Symbol: Slc22a8
Name: solute carrier family 22 member 8
CRRD ID: 632286
Description: Exhibits organic anion transmembrane transporter activity; protein kinase C binding activity; and quaternary ammonium group transmembrane transporter activity. Involved in glutathione transport; quaternary ammonium group transport; and response to methotrexate. Localizes to apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC22A8 (solute carrier family 22 member 8); PARTICIPATES IN ibuprofen pharmacodynamics pathway; ibuprofen pharmacokinetics pathway; bile acid transport pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; 1-naphthyl isothiocyanate; 17beta-estradiol 17-glucosiduronic acid.
Type: protein-coding
Also known as: MGC93369; Oat3; OCT3; organic anion transporter 3; rOAT3; Roct; solute carrier family 22 (organic anion transporter), member 8; solute carrier family 22 ,member 8
Homo sapiens (human) : SLC22A8 (solute carrier family 22 member 8)  HGNC  Alliance
Mus musculus (house mouse) : Slc22a8 (solute carrier family 22 (organic anion transporter), member 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc22a8 (solute carrier family 22 member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC22A8 (solute carrier family 22 member 8)
Canis lupus familiaris (dog) : SLC22A8 (solute carrier family 22 member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc22a8 (solute carrier family 22 member 8)
Sus scrofa (pig) : SLC22A8 (solute carrier family 22 member 8)
Chlorocebus sabaeus (African green monkey) : SLC22A8 (solute carrier family 22 member 8)
Heterocephalus glaber (naked mole-rat) : Slc22a8 (solute carrier family 22 member 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01224,799,444 - 224,818,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,800,252 - 224,818,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01231,735,287 - 231,755,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,269,366 - 211,287,596 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11211,427,795 - 211,446,026 (+)NCBI
Celera1203,011,366 - 203,029,496 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc22a8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 632286
Created: 2003-08-29
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.