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Gene: Pde1c (phosphodiesterase 1C) Rattus norvegicus
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Symbol: Pde1c
Name: phosphodiesterase 1C
Description: Exhibits cAMP binding activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus; response to calcium ion; and sensory perception of smell. Localizes to the neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PDE1C (phosphodiesterase 1C); PARTICIPATES IN protein kinase A (PKA) signaling pathway; calcium/calcium-mediated signaling pathway; purine metabolic pathway; INTERACTS WITH ammonium chloride; bisphenol A; chlorpyrifos.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; cam-PDE 1C; cyclic nucleotide phosphodiesterase 1 C; phosphodiesterase 1C calmodulin-dependent (70kD)
Orthologs:
Homo sapiens (human) : PDE1C (phosphodiesterase 1C)  HGNC  Alliance
Mus musculus (house mouse) : Pde1c (phosphodiesterase 1C)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde1c (phosphodiesterase 1C)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE1C (phosphodiesterase 1C)
Canis lupus familiaris (dog) : PDE1C (phosphodiesterase 1C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde1c (phosphodiesterase 1C)
Sus scrofa (pig) : PDE1C (phosphodiesterase 1C)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0486,359,762 - 86,925,044 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04151,012,195 - 151,485,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,936,642 - 85,448,339 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1485,180,112 - 85,587,782 (-)NCBI
Celera480,156,679 - 80,622,825 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pde1c
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68332
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.