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Gene: Cubn (cubilin) Rattus norvegicus
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Symbol: Cubn
Name: cubilin
Description: Exhibits several functions, including cargo receptor activity; hemoglobin binding activity; and identical protein binding activity. Involved in several processes, including cobalamin catabolic process; endocytic hemoglobin import; and protein homotrimerization. Localizes to several cellular components, including the brush border membrane; cytoplasmic vesicle; and lysosomal lumen. Orthologous to human CUBN (cubilin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 460 kDa receptor; cubilin (intrinsic factor-cobalamin receptor); glycoprotein 280; GP280; IFCR; intrinsic factor-cobalamin receptor; intrinsic factor-vitamin B12 receptor; MGA1
Orthologs:
Homo sapiens (human) : CUBN (cubilin)  HGNC  Alliance
Mus musculus (house mouse) : Cubn (cubilin (intrinsic factor-cobalamin receptor))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cubn (cubilin)
Pan paniscus (bonobo/pygmy chimpanzee) : CUBN (cubilin)
Canis lupus familiaris (dog) : CUBN (cubilin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cubn (cubilin)
Sus scrofa (pig) : CUBN (cubilin)
more info ...
Allele / Splice: Cubnem1Mcwi  
Genetic Models: SS-Cubnem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01780,584,921 - 80,807,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01782,205,509 - 82,425,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41787,545,893 - 87,772,079 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11787,556,725 - 87,782,912 (-)NCBI
Celera1775,753,959 - 75,962,017 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cubn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68355
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.