Gene: Acan (aggrecan) Rattus norvegicus
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Symbol: Acan
Name: aggrecan
Description: Exhibits calcium ion binding activity; involved in several processes, including animal organ development, cellular response to growth factor stimulus, and multicellular organism aging; localizes to several cellular components, including the extracellular space, neuron projection, and neuronal cell body; used to study degenerative disc disease; biomarker of congestive heart failure, degenerative disc disease, osteoarthritis, and status epilepticus; orthologous to human ACAN (aggrecan); INTERACTS WITH (R)-mevalonic acid; (S)-nicotine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Agc; Agc1; aggrecan 1; aggrecan core protein; aggrecan structural proteoglycan of cartilage; aggrecan, structural proteoglycan of cartilage; cartilage-specific proteoglycan core protein; CSPCP
Orthologs:
Homo sapiens (human) : ACAN (aggrecan)  HGNC  Alliance
Mus musculus (house mouse) : Acan (aggrecan)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acan (aggrecan)
Pan paniscus (bonobo/pygmy chimpanzee) : ACAN (aggrecan)
Canis lupus familiaris (dog) : ACAN (aggrecan)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acan (aggrecan)
Sus scrofa (pig) : ACAN (aggrecan)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01140,762,758 - 140,824,441 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01141,732,130 - 141,793,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,787,341 - 134,848,992 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,865,683 - 134,927,335 (+)NCBI
Celera1125,052,984 - 125,114,449 (+)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Acan
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68358
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.