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Gene: Tdo2 (tryptophan 2,3-dioxygenase) Rattus norvegicus
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Symbol: Tdo2
Name: tryptophan 2,3-dioxygenase
Description: Exhibits several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in response to nitroglycerin and tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Tdo; TO; TRPO; tryptamin 2,3-dioxygenase; tryptophan 2,3-dioxygenase A; tryptophan oxygenase; tryptophan pyrrolase; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; tryptophanase
Orthologs:
Homo sapiens (human) : TDO2 (tryptophan 2,3-dioxygenase)  HGNC  Alliance
Mus musculus (house mouse) : Tdo2 (tryptophan 2,3-dioxygenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdo2 (tryptophan 2,3-dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : TDO2 (tryptophan 2,3-dioxygenase)
Canis lupus familiaris (dog) : TDO2 (tryptophan 2,3-dioxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdo2 (tryptophan 2,3-dioxygenase)
Sus scrofa (pig) : TDO2 (tryptophan 2,3-dioxygenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02180,897,059 - 180,914,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2180,897,011 - 180,914,940 (-)Ensembl
Rnor_5.02200,305,349 - 200,323,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,594,020 - 173,611,833 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,544,125 - 173,561,939 (-)NCBI
Celera2161,299,362 - 161,317,278 (-)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21078.8RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tdo2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68370
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.