Gene: Mtor (mechanistic target of rapamycin kinase) Rattus norvegicus
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Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Description: Exhibits several functions, including protein domain specific binding activity, protein kinase binding activity, and protein serine/threonine kinase activity; involved in several processes, including negative regulation of cellular metabolic process, nervous system development, and positive regulation of cell population proliferation; localizes to several cellular components, including the TORC1 complex, glutamatergic synapse, and nucleus; colocalizes with the dendrite and neuronal cell body; used to study several diseases, including artery disease (multiple), autosomal recessive polycystic kidney disease, chondrosarcoma, epilepsy (multiple), and kidney failure (multiple); biomarker of several diseases, including middle cerebral artery infarction, obesity, polycystic kidney disease, type 2 diabetes mellitus, and ureteral obstruction; orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN mTOR signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Frap1; mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); RAFT1; rapamycin and FKBP12 target-1 protein; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
Orthologs:
Homo sapiens (human) : MTOR (mechanistic target of rapamycin kinase)  HGNC  Alliance
Mus musculus (house mouse) : Mtor (mechanistic target of rapamycin kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mtor (mechanistic target of rapamycin kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTOR (mechanistic target of rapamycin kinase)
Canis lupus familiaris (dog) : MTOR (mechanistic target of rapamycin kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mtor (mechanistic target of rapamycin kinase)
Sus scrofa (pig) : MTOR (mechanistic target of rapamycin kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mtor
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68371
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.