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Gene: Alas1 (5'-aminolevulinate synthase 1) Rattus norvegicus
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Symbol: Alas1
Name: 5'-aminolevulinate synthase 1
Description: Exhibits 5-aminolevulinate synthase activity. Involved in several processes, including response to cAMP; response to nickel cation; and response to platinum ion. Localizes to the mitochondrion. Biomarker of porphyria and pulmonary hypertension. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1); PARTICIPATES IN heme biosynthetic pathway; acute intermittent porphyria pathway; dihydropyrimidine dehydrogenase deficiency pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; 1,2,4-trichlorobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALA-S; ALAS; ALAS-H; ALAS-N; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1
Orthologs:
Homo sapiens (human) : ALAS1 (5'-aminolevulinate synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Alas1 (aminolevulinic acid synthase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alas1 (5'-aminolevulinate synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALAS1 (5'-aminolevulinate synthase 1)
Canis lupus familiaris (dog) : ALAS1 (5'-aminolevulinate synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alas1 (5'-aminolevulinate synthase 1)
Sus scrofa (pig) : ALAS1 (aminolevulinate, delta-, synthase 1 pseudogene)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08114,927,704 - 114,941,038 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08114,289,617 - 114,302,413 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8106,197,419 - 106,210,677 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Alas1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68392
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.