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Gene: Dbt (dihydrolipoamide branched chain transacylase E2) Rattus norvegicus
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Symbol: Dbt
Name: dihydrolipoamide branched chain transacylase E2
Description: Predicted to have acetyltransferase activity; lipoic acid binding activity; and ubiquitin protein ligase binding activity. Predicted to localize to the mitochondrial nucleoid. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DBT (dihydrolipoamide branched chain transacylase E2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (RS)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Orthologs:
Homo sapiens (human) : DBT (dihydrolipoamide branched chain transacylase E2)  HGNC  Alliance
Mus musculus (house mouse) : Dbt (dihydrolipoamide branched chain transacylase E2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dbt (dihydrolipoamide branched chain transacylase E2)
Pan paniscus (bonobo/pygmy chimpanzee) : DBT (dihydrolipoamide branched chain transacylase E2)
Canis lupus familiaris (dog) : DBT (dihydrolipoamide branched chain transacylase E2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dbt (dihydrolipoamide branched chain transacylase E2)
Sus scrofa (pig) : DBT (dihydrolipoamide branched chain transacylase E2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02219,563,783 - 219,592,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,563,783 - 219,592,650 (+)Ensembl
Rnor_5.02237,625,211 - 237,654,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,759,312 - 212,788,180 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12212,731,165 - 212,742,429 (+)NCBI
Celera2196,974,438 - 197,002,611 (+)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dbt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68403
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.