Gene: Epas1 (endothelial PAS domain protein 1) Rattus norvegicus
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Symbol: Epas1
Name: endothelial PAS domain protein 1
Description: Exhibits DNA-binding transcription factor activity and cobalt ion binding activity; contributes to sequence-specific DNA binding activity; involved in several processes, including cellular response to hypoxia, cellular response to interleukin-1, and regulation of cellular biosynthetic process; localizes to the cytoplasm and nucleus; used to study acute kidney failure and intermittent claudication; biomarker of artery disease (multiple), glucose metabolism disease (multiple), polycystic kidney disease, and renal cell carcinoma; orthologous to human EPAS1 (endothelial PAS domain protein 1); PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 1H-benzimidazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endothelial PAS domain-containing protein 1; EPAS-1; HIF-2 alpha; HIF-2-alpha; HIF2 alpha; HIF2-alpha; Hif2a; HLF; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha
Orthologs:
Homo sapiens (human) : EPAS1 (endothelial PAS domain protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Epas1 (endothelial PAS domain protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epas1 (endothelial PAS domain protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPAS1 (endothelial PAS domain protein 1)
Canis lupus familiaris (dog) : EPAS1 (endothelial PAS domain protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epas1 (endothelial PAS domain protein 1)
Sus scrofa (pig) : EPAS1 (endothelial PAS domain protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0610,306,508 - 10,385,239 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0620,299,603 - 20,379,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,203,108 - 10,297,215 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1610,203,107 - 10,297,215 (+)NCBI
Celera67,526,511 - 7,605,382 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Epas1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68404
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.