Gene: Lrp2 (LDL receptor related protein 2) Rattus norvegicus
Symbol: Lrp2
Name: LDL receptor related protein 2
Description: Exhibits several functions, including PDZ domain binding activity, drug binding activity, and signaling receptor binding activity; involved in several processes, including aging, animal organ regeneration, and positive regulation of transport; localizes to several cellular components, including the apical plasma membrane, cell surface, and plasma membrane bounded cell projection part; used to study hypertension; biomarker of autosomal dominant polycystic kidney disease, end stage renal failure, membranous glomerulonephritis, and nephrosis; orthologous to human LRP2 (LDL receptor related protein 2); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: glycoprotein 330; gp330; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; LRP-2; megalin
Homo sapiens (human) : LRP2 (LDL receptor related protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Lrp2 (low density lipoprotein receptor-related protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp2 (LDL receptor related protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP2 (LDL receptor related protein 2)
Canis lupus familiaris (dog) : LRP2 (LDL receptor related protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp2 (LDL receptor related protein 2)
Sus scrofa (pig) : LRP2 (LDL receptor related protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lrp2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68407
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.