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Gene: Dlc1 (DLC1 Rho GTPase activating protein) Rattus norvegicus
Symbol: Dlc1
Name: DLC1 Rho GTPase activating protein
Description: Exhibits GTPase activator activity; phospholipase binding activity; and vinculin binding activity. Involved in activation of phospholipase C activity; cellular response to insulin stimulus; and cytoskeleton organization. Localizes to membrane raft. Colocalizes with actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Arhgap7; deleted in liver cancer 1; deleted in liver cancer 1 protein homolog; dlc-1; p122-RhoGAP; rho GTPase activating protein 7; rho GTPase-activating protein 7; rho-type GTPase-activating protein 7; RhoGAP; stAR-related lipid transfer protein 12; stARD12; START domain-containing protein 12
Homo sapiens (human) : DLC1 (DLC1 Rho GTPase activating protein)  HGNC  Alliance
Mus musculus (house mouse) : Dlc1 (deleted in liver cancer 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlc1 (DLC1 Rho GTPase activating protein)
Pan paniscus (bonobo/pygmy chimpanzee) : DLC1 (DLC1 Rho GTPase activating protein)
Canis lupus familiaris (dog) : DLC1 (DLC1 Rho GTPase activating protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlc1 (DLC1 Rho GTPase activating protein)
Sus scrofa (pig) : DLC1 (DLC1 Rho GTPase activating protein)
Chlorocebus sabaeus (African green monkey) : DLC1 (DLC1 Rho GTPase activating protein)
Heterocephalus glaber (naked mole-rat) : Dlc1 (DLC1 Rho GTPase activating protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01658,776,489 - 59,247,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1659,077,574 - 59,247,754 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01658,638,567 - 58,928,425 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41659,312,930 - 59,355,129 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11659,313,004 - 59,355,204 (+)NCBI
Celera1653,351,212 - 53,453,368 (+)NCBICelera
Celera1653,685,682 - 53,727,187 (+)NCBICelera
Cytogenetic Map16q12.1-q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dlc1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68416
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.