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Gene: Dlg4 (discs large MAGUK scaffold protein 4) Rattus norvegicus
Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
Description: Exhibits several functions, including PDZ domain binding activity; enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Localizes to several cellular components, including anchored component of postsynaptic density membrane; dendrite; and juxtaparanode region of axon. Colocalizes with voltage-gated potassium channel complex. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4); PARTICIPATES IN glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
Also known as: discs large homolog 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlgh4; postsynaptic density protein 95; PSD-95; PSD95; SAP-90; Sap90; synapse-associated protein 90; synapse-associated protein SAP90
Homo sapiens (human) : DLG4 (discs large MAGUK scaffold protein 4)  HGNC  Alliance
Mus musculus (house mouse) : Dlg4 (discs large MAGUK scaffold protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg4 (discs large MAGUK scaffold protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG4 (discs large MAGUK scaffold protein 4)
Canis lupus familiaris (dog) : DLG4 (discs large MAGUK scaffold protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg4 (discs large MAGUK scaffold protein 4)
Sus scrofa (pig) : DLG4 (discs large MAGUK scaffold protein 4)
Chlorocebus sabaeus (African green monkey) : DLG4 (discs large MAGUK scaffold protein 4)
Heterocephalus glaber (naked mole-rat) : Dlg4 (discs large MAGUK scaffold protein 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01056,625,845 - 56,655,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,627,411 - 56,653,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,369,703 - 56,400,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,864,459 - 56,890,626 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11056,878,081 - 56,904,246 (+)NCBI
Celera1053,894,685 - 53,920,691 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dlg4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68424
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.