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Gene: Clcnka (chloride voltage-gated channel Ka) Rattus norvegicus
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Symbol: Clcnka
Name: chloride voltage-gated channel Ka
Description: Exhibits chloride channel activity and voltage-gated ion channel activity. Involved in several processes, including body fluid secretion; response to calcium ion; and response to water deprivation. Localizes to several cellular components, including apical plasma membrane; basolateral plasma membrane; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Bartter disease type 4b and sensorineural hearing loss. Orthologous to human CLCNKA (chloride voltage-gated channel Ka); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (4-chloro-2-methylphenoxy)acetic acid; 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: chloride channel K1; chloride channel Ka; chloride channel protein ClC-Ka; chloride channel, voltage-sensitive Ka; clC-K1; Clcnk1; MGC93313
Orthologs:
Homo sapiens (human) : CLCNKA (chloride voltage-gated channel Ka)  HGNC  Alliance
Mus musculus (house mouse) : Clcnka (chloride channel, voltage-sensitive Ka)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CLCNKA (chloride voltage-gated channel Ka)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcnka (chloride voltage-gated channel Ka)
Heterocephalus glaber (naked mole-rat) : Clcnka (chloride voltage-gated channel Ka)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05159,931,497 - 159,946,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,651,964 - 163,667,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,274,377 - 160,290,369 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15160,284,564 - 160,300,557 (-)NCBI
Celera5152,055,371 - 152,067,986 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Clcnka
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68435
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.