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Gene: Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1) Rattus norvegicus
Symbol: Gucy1a1
Name: guanylate cyclase 1 soluble subunit alpha 1
CRRD ID: 68436
Description: Exhibits ion binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Involved in response to herbicide and response to organic cyclic compound. Localizes to guanylate cyclase complex, soluble. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Type: protein-coding
Also known as: GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1 soluble subunit alpha 3; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); Gucy1a3; SGC; soluble guanylate cyclase; soluble guanylate cyclase large subunit
Homo sapiens (human) : GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1)  HGNC  Alliance
Mus musculus (house mouse) : Gucy1a1 (guanylate cyclase 1, soluble, alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1)
Canis lupus familiaris (dog) : GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1)
Sus scrofa (pig) : GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1)
Chlorocebus sabaeus (African green monkey) : GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1)
Heterocephalus glaber (naked mole-rat) : Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1)
more info ...
Allele / Splice: Gucy1a3em1Mcwi  
Genetic Models: SS-Gucy1a3em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02181,045,694 - 181,103,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,453,480 - 200,515,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,756,824 - 173,818,316 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,705,122 - 173,768,506 (-)NCBI
Celera2161,450,514 - 161,511,622 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gucy1a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68436
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.