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Gene: Oprl1 (opioid related nociceptin receptor 1) Rattus norvegicus
Symbol: Oprl1
Name: opioid related nociceptin receptor 1
CRRD ID: 68438
Description: Exhibits protein C-terminus binding activity. Involved in several processes, including conditioned place preference; estrous cycle; and positive regulation of sensory perception of pain. Localizes to membrane. Used to study alcohol use disorder. Biomarker of sciatic neuropathy. Orthologous to human OPRL1 (opioid related nociceptin receptor 1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: kappa-type 3 opioid receptor; KOR-3; KOR3; LC132; MOR-C; nociceptin receptor; nociceptin receptor ORL1; OFQR; opiate receptor-like 1; opioid receptor-like; opioid receptor-like 1; Oprl; ORL1; orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR1
Homo sapiens (human) : OPRL1 (opioid related nociceptin receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Oprl1 (opioid receptor-like 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oprl1 (opioid related nociceptin receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : OPRL1 (opioid related nociceptin receptor 1)
Canis lupus familiaris (dog) : OPRL1 (opioid related nociceptin receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oprl1 (opioid related nociceptin receptor 1)
Sus scrofa (pig) : OPRL1 (opioid related nociceptin receptor 1)
Chlorocebus sabaeus (African green monkey) : OPRL1 (opioid related nociceptin receptor 1)
Heterocephalus glaber (naked mole-rat) : Oprl1 (opioid related nociceptin receptor 1)
more info ...
Allele / Splice: Oprl1m1Hubr  
Genetic Models: WI-Oprl1m1Hubr-/- WI-Oprl1m1Hubr+/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03177,223,779 - 177,231,663 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,225,737 - 177,231,663 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,932,344 - 180,943,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,869,862 - 170,873,417 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13170,775,328 - 170,780,949 (+)NCBI
Celera3163,747,719 - 163,753,636 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Oprl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68438
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.