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Gene: Bhlhe40 (basic helix-loop-helix family, member e40) Rattus norvegicus
Symbol: Bhlhe40
Name: basic helix-loop-helix family, member e40
Description: Predicted to have several functions, including RNA polymerase II regulatory region sequence-specific DNA binding activity; protein dimerization activity; and transcription factor binding activity. Involved in several processes, including circadian rhythm; negative regulation of transcription by RNA polymerase II; and regulation of neuronal synaptic plasticity. Localizes to the nucleus. Orthologous to human BHLHE40 (basic helix-loop-helix family member e40); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3-dinitrobenzene.
Type: protein-coding
Also known as: basic helix-loop-helix domain containing, class B2; Bhlhb2; class B basic helix-loop-helix protein 2; class E basic helix-loop-helix protein 40; Dec1; enhancer-of split and hairy-related protein 2; enhancer-of-split and hairy-related protein 2; SHARP-2; Sharp2; stimulated by retinoic acid 14; Stra13; Stra14
Homo sapiens (human) : BHLHE40 (basic helix-loop-helix family member e40)  HGNC  Alliance
Mus musculus (house mouse) : Bhlhe40 (basic helix-loop-helix family, member e40)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bhlhe40 (basic helix-loop-helix family member e40)
Pan paniscus (bonobo/pygmy chimpanzee) : BHLHE40 (basic helix-loop-helix family member e40)
Canis lupus familiaris (dog) : BHLHE40 (basic helix-loop-helix family member e40)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bhlhe40 (basic helix-loop-helix family member e40)
Sus scrofa (pig) : BHLHE40 (basic helix-loop-helix family member e40)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04140,703,619 - 140,709,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04205,170,129 - 205,175,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,139,486 - 144,145,186 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14144,384,326 - 144,390,027 (+)NCBI
Celera4130,269,971 - 130,275,671 (+)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bhlhe40
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68439
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.