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Gene: Ighmbp2 (immunoglobulin mu binding protein 2) Mus musculus
Symbol: Ighmbp2
Name: immunoglobulin mu binding protein 2
Description: Exhibits G-rich single-stranded DNA binding activity and ribosome binding activity. Involved in negative regulation of transcription by RNA polymerase II; neuromuscular process; and spinal cord motor neuron differentiation. Localizes to several cellular components, including the growth cone; neuronal cell body; and perinuclear region of cytoplasm. Used to study distal spinal muscular atrophy 1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and distal spinal muscular atrophy 1. Is expressed in several structures, including genitourinary system; heart; liver; lung; and nervous system. Orthologous to human IGHMBP2 (immunoglobulin mu DNA binding protein 2); INTERACTS WITH 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AEP; antifreeze enhancer-binding protein; ATP-dependent helicase IGHMBP2; cardiac transcription factor 1; Catf1; DNA-binding protein SMUBP-2; immunoglobulin mu-binding protein 2; immunoglobulin S mu binding protein 2; neuromuscular degeneration; nmd; p110 subunit; RIPE3b1; sma; Smbp-2; Smbp2; Smubp2
Homo sapiens (human) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ighmbp2 (immunoglobulin mu DNA binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ighmbp2 (immunoglobulin mu DNA binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Canis lupus familiaris (dog) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ighmbp2 (immunoglobulin mu DNA binding protein 2)
Sus scrofa (pig) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Chlorocebus sabaeus (African green monkey) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Heterocephalus glaber (naked mole-rat) : Ighmbp2 (immunoglobulin mu DNA binding protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl193,259,076 - 3,283,017 (-)Ensembl
GRCm38193,259,076 - 3,283,010 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37193,259,076 - 3,283,010 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,259,076 - 3,282,906 (-)NCBImm8
Celera193,128,514 - 3,152,444 (-)NCBICelera
Cytogenetic Map19 ANCBI
cM Map193.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ighmbp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68451
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.