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Gene: VAPB (VAMP associated protein B and C) Homo sapiens
Symbol: VAPB
Name: VAMP associated protein B and C
CRRD ID: 68452
Description: Exhibits several functions, including FFAT motif binding activity; protein dimerization activity; and tubulin binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; modulation by host of viral process; and negative regulation by virus of viral protein levels in host cell. Localizes to Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum membrane. Implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS8; VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-associated 33 kDa protein; VAMP-associated protein B; VAMP-associated protein B/C; VAMP-associated protein C; VAMP-B; VAMP-B/VAMP-C; VAMP-C; VAP-B; VAP-B/VAP-C; VAP-C; vesicle-associated membrane protein, associated protein b and c; vesicle-associated membrane protein-associated protein B/C
Mus musculus (house mouse) : Vapb (vesicle-associated membrane protein, associated protein B and C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vapb (VAMP associated protein B and C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vapb (VAMP associated protein B and C)
Pan paniscus (bonobo/pygmy chimpanzee) : VAPB (VAMP associated protein B and C)
Canis lupus familiaris (dog) : VAPB (VAMP associated protein B and C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vapb (VAMP associated protein B and C)
Sus scrofa (pig) : VAPB (VAMP associated protein B and C)
Chlorocebus sabaeus (African green monkey) : VAPB (VAMP associated protein B and C)
Heterocephalus glaber (naked mole-rat) : Vapb (VAMP associated protein B and C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2058,389,229 - 58,451,101 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2058,389,122 - 58,451,101 (+)EnsemblGRCh38hg38GRCh38
GRCh382058,389,211 - 58,451,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372056,964,175 - 57,026,157 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,397,651 - 56,455,369 (+)NCBINCBI36hg18NCBI36
Build 342056,397,650 - 56,455,367NCBI
Celera2053,704,711 - 53,762,426 (+)NCBI
Cytogenetic Map20q13.32NCBI
HuRef2053,747,058 - 53,809,032 (+)NCBIHuRef
CHM1_12056,865,734 - 56,927,715 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on VAPB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68452
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.