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Gene: Htt (huntingtin) Mus musculus
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Symbol: Htt
Name: huntingtin
Description: Exhibits diazepam binding activity and transcription factor binding activity. Involved in several processes, including carboxylic acid metabolic process; positive regulation of cilium assembly; and transport along microtubule. Localizes to several cellular components, including centriole; glutamatergic synapse; and perinuclear region of cytoplasm. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Orthologous to human HTT (huntingtin); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI256365; C430023I11Rik; Hd; HD protein homolog; Hdh; Huntington disease gene homolog; huntington disease protein homolog; IT15
Orthologs:
Homo sapiens (human) : HTT (huntingtin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Htt (huntingtin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htt (huntingtin)
Pan paniscus (bonobo/pygmy chimpanzee) : HTT (huntingtin)
Canis lupus familiaris (dog) : HTT (huntingtin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htt (huntingtin)
Sus scrofa (pig) : HTT (huntingtin)
Chlorocebus sabaeus (African green monkey) : HTT (huntingtin)
Heterocephalus glaber (naked mole-rat) : Htt (huntingtin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl534,761,740 - 34,912,534 (+)EnsemblGRCm38mm10GRCm38
GRCm38534,761,721 - 34,912,534 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37535,104,389 - 35,252,045 (+)NCBIGRCm37mm9NCBIm37
MGSCv36535,078,597 - 35,226,253 (+)NCBImm8
Celera532,235,862 - 32,383,257 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Htt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68473
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-05-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.