Gene: NR5A2 (nuclear receptor subfamily 5 group A member 2) Homo sapiens
Analyze
Symbol:
NR5A2
Name:
nuclear receptor subfamily 5 group A member 2
Description:
Exhibits DNA binding activity; DNA-binding transcription factor activity; and phospholipid binding activity. Involved in positive regulation of transcription, DNA-templated and positive regulation of viral genome replication. Localizes to the cytoplasm and nucleus.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
alpha-1-fetoprotein transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; B1F; B1F2; CPF; CYP7A promoter-binding factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTZ-F1; FTZ-F1beta; hB1F; hB1F-2; hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; liver nuclear receptor homolog-1 variant 2; liver receptor homolog 1; liver receptor homolog-1; LRH-1; LRH1; nuclear receptor NR5A2; nuclear receptor subfamily 5, group A, member 2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Nr5a2 (nuclear receptor subfamily 5, group A, member 2)
HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Nr5a2 (nuclear receptor subfamily 5, group A, member 2)
HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
Nr5a2 (nuclear receptor subfamily 5 group A member 2)
NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
NR5A2 (nuclear receptor subfamily 5 group A member 2)
NCBI
Ortholog
Canis lupus familiaris (dog):
NR5A2 (nuclear receptor subfamily 5 group A member 2)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nr5a2 (nuclear receptor subfamily 5 group A member 2)
NCBI
Ortholog
Sus scrofa (pig):
NR5A2 (nuclear receptor subfamily 5 group A member 2)
HGNC
EggNOG, Ensembl, NCBI, OrthoDB, Panther
Other homologs 2
Rattus norvegicus (Norway rat):
Nr5a1 (nuclear receptor subfamily 5, group A, member 1)
HGNC
OrthoDB
Mus musculus (house mouse):
Nr5a1 (nuclear receptor subfamily 5, group A, member 1)
HGNC
OrthoDB
Canis lupus familiaris (dog):
NR6A1 (nuclear receptor subfamily 6 group A member 1)
HGNC
OrthoDB
Sus scrofa (pig):
NR5A1 (nuclear receptor subfamily 5 group A member 1)
HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Nr5a2 (nuclear receptor subfamily 5, group A, member 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Nr5a2 (nuclear receptor subfamily 5, group A, member 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
nr5a5 (nuclear receptor subfamily 5, group A, member 5)
Alliance
DIOPT (OrthoFinder, PANTHER, Roundup, TreeFam, ZFIN)
Danio rerio (zebrafish):
nr5a2 (nuclear receptor subfamily 5, group A, member 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
nhr-25
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
ftz-f1
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 1 200,027,710 - 200,177,424 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 1 199,996,730 - 200,146,552 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 1 198,263,393 - 198,413,175 (+) NCBI NCBI36 hg18 NCBI36 Build 34 1 196,728,426 - 196,878,205 NCBI Celera 1 173,119,461 - 173,269,192 (+) NCBI Cytogenetic Map 1 q32.1 NCBI HuRef 1 171,163,369 - 171,312,952 (+) NCBI HuRef CHM1_1 1 201,419,353 - 201,569,071 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
long QT syndrome IAGP RGD:10395419 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:26132555 microphthalmia IAGP RGD:11040274 8554872 ClinVar Annotator: match by term: Anophthalmia - microphthalmia ClinVar PMID:26893459 Microphthalmia, Syndromic 1 IAGP RGD:11040274 8554872 ClinVar Annotator: match by term: Anophthalmia - microphthalmia ClinVar PMID:26893459
Imported Annotations - CTD
anovulation EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18628394 Chemical and Drug Induced Liver Injury EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29515023 Dyslipidemias EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29515023 Female Infertility EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17409375 glucose intolerance EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29515023 Hepatomegaly EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29515023 non-alcoholic fatty liver disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29515023 pancreatic cancer EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20101243 , PMID:26098869
(-)-demecolcine increases expression EXP 6480464 Demecolcine results in increased expression of NR5A2 mRNA CTD PMID:23649840 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactions ISO RGD:68353 6480464 2 more ... CTD PMID:19414516 1,2-dilauroyl-sn-glycero-3-phosphocholine(1+) increases expression ISO RGD:68500 6480464 1, 2-dilauroylphosphatidylcholine results in increased expression of NR5A2 CTD PMID:24459144 1-O-oleoyl-sn-glycero-3-phosphocholine multiple interactions ISO RGD:68500 6480464 [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:29515023 17alpha-ethynylestradiol increases expression ISO RGD:68500 6480464 Ethinyl Estradiol results in increased expression of NR5A2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:68500 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:68353 6480464 Ethinyl Estradiol results in decreased expression of NR5A2 mRNA CTD PMID:15834898 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of NR5A2 mRNA CTD PMID:20607599 17beta-estradiol decreases abundance ISO RGD:68500 6480464 NR5A2 protein results in decreased abundance of Estradiol CTD PMID:18628394 17beta-estradiol multiple interactions ISO RGD:68500 6480464 [[NR5A2 protein results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estradiol, [NR5A2 results in increased expression of NOS3 mRNA] which results in decreased abundance of Estradiol CTD PMID:18628394 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of NR5A2 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:68500 6480464 Tetrachlorodibenzodioxin results in increased expression of NR5A2 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:68500 6480464 Tetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNA CTD PMID:29452137 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [Tetrachlorodibenzodioxin results in increased expression of NR5A2 mRNA] CTD PMID:29704546 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:68500 6480464 Tetrachlorodibenzodioxin affects the expression of NR5A2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:68500 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A2 mRNA more ... CTD PMID:17942748 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of NR5A2 mRNA CTD PMID:20106945 , PMID:29704546 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNA CTD PMID:17517823 2-methoxyethanol multiple interactions ISO RGD:68353 6480464 Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA] CTD PMID:21427058 2-methoxyethanol increases expression ISO RGD:68353 6480464 methyl cellosolve results in increased expression of NR5A2 mRNA CTD PMID:21427058 4,4'-diaminodiphenylmethane decreases expression ISO RGD:68500 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of NR5A2 mRNA CTD PMID:18648102 5-fluorouracil affects expression ISO RGD:68500 6480464 Fluorouracil affects the expression of NR5A2 protein CTD PMID:21296659 9-cis-retinoic acid decreases expression EXP 6480464 Alitretinoin results in decreased expression of NR5A2 mRNA CTD PMID:16357189 9-cis-retinoic acid multiple interactions EXP 6480464 Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]], Alitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA] CTD PMID:16357189 acetic acid decreases expression ISO RGD:68500 6480464 Acetic Acid results in decreased expression of NR5A2 protein CTD PMID:21296659 aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of NR5A2 intron CTD PMID:30157460 aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of NR5A2 gene CTD PMID:27153756 aflatoxin B1 multiple interactions ISO RGD:68353 6480464 [sulforafan co-treated with Aflatoxin B1] affects the expression of NR5A2 mRNA CTD PMID:25450479 aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of NR5A2 protein CTD PMID:20106945 aflatoxin B2 decreases methylation EXP 6480464 aflatoxin B2 results in decreased methylation of NR5A2 intron CTD PMID:30157460 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of NR5A2 mRNA CTD PMID:21934132 ammonium chloride affects expression ISO RGD:68353 6480464 Ammonium Chloride affects the expression of NR5A2 mRNA CTD PMID:16483693 androst-4-ene-3,17-dione increases expression ISO RGD:68353 6480464 Androstenedione results in increased expression of NR5A2 mRNA CTD PMID:21273442 androst-4-ene-3,17-dione multiple interactions ISO RGD:68353 6480464 AR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA] CTD PMID:21273442 arachidonic acid decreases chemical synthesis ISO RGD:68500 6480464 NR5A2 gene mutant form results in decreased chemical synthesis of Arachidonic Acid CTD PMID:29515023 arachidonic acid multiple interactions ISO RGD:68500 6480464 [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in decreased abundance of Arachidonic Acid analog CTD PMID:29515023 arsane affects methylation EXP 6480464 Arsenic affects the methylation of NR5A2 gene CTD PMID:25304211 arsenic atom affects methylation EXP 6480464 Arsenic affects the methylation of NR5A2 gene CTD PMID:25304211 arsenite(3-) increases methylation EXP 6480464 arsenite results in increased methylation of NR5A2 promoter CTD PMID:23974009 atrazine increases activity EXP 6480464 Atrazine results in increased activity of NR5A2 protein CTD PMID:18461179 aztreonam increases expression ISO RGD:68500 6480464 Aztreonam results in increased expression of NR5A2 mRNA CTD PMID:24657338 benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of NR5A2 intron CTD PMID:30157460 benzo[e]pyrene decreases methylation EXP 6480464 benzo(e)pyrene results in decreased methylation of NR5A2 intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:68500 6480464 Diethylhexyl Phthalate results in decreased expression of NR5A2 mRNA CTD PMID:25975992 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:68353 6480464 Diethylhexyl Phthalate results in decreased expression of NR5A2 mRNA CTD PMID:29945229 bisphenol A increases expression ISO RGD:68500 6480464 bisphenol A results in increased expression of NR5A2 mRNA CTD PMID:26063408 , PMID:30951980 bisphenol A increases methylation ISO RGD:68353 6480464 bisphenol A results in increased methylation of NR5A2 gene CTD PMID:28505145 bisphenol A affects methylation ISO RGD:68500 6480464 bisphenol A affects the methylation of NR5A2 promoter CTD PMID:27334623 bisphenol A affects expression ISO RGD:68353 6480464 bisphenol A affects the expression of NR5A2 mRNA CTD PMID:25181051 bromochloroacetic acid increases expression ISO RGD:68500 6480464 bromochloroacetic acid results in increased expression of NR5A2 protein CTD PMID:21296659 bromocriptine multiple interactions ISO RGD:68353 6480464 Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA] CTD PMID:21427058 C60 fullerene decreases expression ISO RGD:68353 6480464 fullerene C60 results in decreased expression of NR5A2 mRNA CTD PMID:19167457 carbon nanotube decreases expression ISO RGD:68500 6480464 Nanotubes, Carbon analog results in decreased expression of NR5A2 mRNA, Nanotubes, Carbon results in decreased expression of NR5A2 mRNA CTD PMID:25620056 cefalotin multiple interactions ISO RGD:68500 6480464 [Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA CTD PMID:24657338 cholesterol affects abundance ISO RGD:68500 6480464 NR5A2 gene mutant form affects the abundance of Cholesterol CTD PMID:29515023 choline multiple interactions ISO RGD:68500 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of NR5A2, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR5A2 gene CTD PMID:20938992 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of NR5A2 mRNA CTD PMID:27392435 clofibrate increases expression ISO RGD:68500 6480464 Clofibrate results in increased expression of NR5A2 mRNA CTD PMID:28973556 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of NR5A2 mRNA CTD PMID:19320972 cobalt dichloride decreases expression ISO RGD:68353 6480464 cobaltous chloride results in decreased expression of NR5A2 mRNA CTD PMID:24386269 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]], NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA] CTD PMID:16357189 Colforsin dapropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of NR5A2 mRNA CTD PMID:16357189 crocidolite asbestos increases methylation EXP 6480464 Asbestos, Crocidolite results in increased methylation of NR5A2 gene CTD PMID:29523930 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of NR5A2 mRNA CTD PMID:20106945 , PMID:27989131 dexamethasone decreases expression ISO RGD:68353 6480464 Dexamethasone results in decreased expression of NR5A2 mRNA CTD PMID:20888898 dextran sulfate multiple interactions ISO RGD:68500 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NR5A2 mRNA CTD PMID:29950665 dibenz[a,h]anthracene increases expression ISO RGD:68500 6480464 1 more ... CTD PMID:26377693 diethylstilbestrol increases expression ISO RGD:68500 6480464 Diethylstilbestrol results in increased expression of NR5A2 mRNA CTD PMID:22100434 endosulfan affects expression ISO RGD:68353 6480464 Endosulfan affects the expression of NR5A2 mRNA CTD PMID:29391264 flutamide decreases expression ISO RGD:68353 6480464 Flutamide results in decreased expression of NR5A2 mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:68500 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of NR5A2, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR5A2 gene CTD PMID:20938992 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of NR5A2 mRNA CTD PMID:23649840 genistein increases expression ISO RGD:68500 6480464 Genistein results in increased expression of NR5A2 mRNA CTD PMID:22553218 imipenem hydrate multiple interactions ISO RGD:68500 6480464 [Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA CTD PMID:24657338 L-methionine multiple interactions ISO RGD:68500 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of NR5A2, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR5A2 gene CTD PMID:20938992 lead nitrate increases expression ISO RGD:68500 6480464 lead nitrate results in increased expression of NR5A2 mRNA CTD PMID:16049268 linoleic acid multiple interactions ISO RGD:68500 6480464 [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Linoleic Acid analog CTD PMID:29515023 lithocholic acid decreases expression ISO RGD:68353 6480464 Lithocholic Acid results in decreased expression of NR5A2 mRNA CTD PMID:20888898 lysophosphatidylcholine multiple interactions ISO RGD:68500 6480464 [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Lysophosphatidylcholines CTD PMID:29515023 lysophosphatidylethanolamine multiple interactions ISO RGD:68500 6480464 [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine, [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine analog CTD PMID:29515023 methapyrilene decreases methylation EXP 6480464 Methapyrilene results in decreased methylation of NR5A2 intron CTD PMID:30157460 methapyrilene decreases expression ISO RGD:68353 6480464 Methapyrilene results in decreased expression of NR5A2 mRNA CTD PMID:30467583 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of NR5A2 mRNA CTD PMID:23903816 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of NR5A2 mRNA CTD PMID:24810058 N-nitrosodiethylamine multiple interactions ISO RGD:68353 6480464 bicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of NR5A2 mRNA] CTD PMID:17106253 N-nitrosodiethylamine increases expression ISO RGD:68353 6480464 Diethylnitrosamine results in increased expression of NR5A2 mRNA CTD PMID:17106253 neomycin multiple interactions ISO RGD:68500 6480464 [Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA CTD PMID:24657338 nitrofen decreases expression ISO RGD:68353 6480464 nitrofen results in decreased expression of NR5A2 mRNA CTD PMID:26720608 obeticholic acid decreases expression EXP 6480464 obeticholic acid results in decreased expression of NR5A2 mRNA CTD PMID:27939613 ozone decreases expression ISO RGD:68500 6480464 Ozone results in decreased expression of NR5A2 mRNA CTD PMID:16183385 p-toluidine increases expression ISO RGD:68353 6480464 4-toluidine results in increased expression of NR5A2 mRNA CTD PMID:27638505 paracetamol decreases expression ISO RGD:68500 6480464 Acetaminophen results in decreased expression of NR5A2 mRNA CTD PMID:17585979 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of NR5A2 mRNA CTD PMID:21420995 , PMID:29067470 paracetamol affects expression ISO RGD:68500 6480464 Acetaminophen affects the expression of NR5A2 mRNA CTD PMID:17562736 phenobarbital multiple interactions ISO RGD:68500 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of NR5A2 mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:68500 6480464 Phenobarbital affects the expression of NR5A2 mRNA CTD PMID:23091169 phenobarbital increases expression ISO RGD:68500 6480464 Phenobarbital results in increased expression of NR5A2 mRNA CTD PMID:19482888 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]], NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA] CTD PMID:16357189 phosphatidylcholine multiple interactions ISO RGD:68500 6480464 [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Phosphatidylcholines CTD PMID:29515023 pirinixic acid decreases expression ISO RGD:68500 6480464 pirinixic acid results in decreased expression of NR5A2 mRNA CTD PMID:18445702 potassium dichromate decreases expression ISO RGD:68500 6480464 Potassium Dichromate results in decreased expression of NR5A2 mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:68353 6480464 Pregnenolone Carbonitrile results in decreased expression of NR5A2 mRNA CTD PMID:20888898 progesterone decreases abundance ISO RGD:68500 6480464 NR5A2 gene mutant form results in decreased abundance of Progesterone CTD PMID:17409375 progesterone increases abundance ISO RGD:68500 6480464 NR5A2 protein results in increased abundance of Progesterone CTD PMID:18628394 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of NR5A2 mRNA CTD PMID:29301061 succimer multiple interactions ISO RGD:68500 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NR5A2 mRNA CTD PMID:26378955 sulforaphane multiple interactions ISO RGD:68353 6480464 [sulforafan co-treated with Aflatoxin B1] affects the expression of NR5A2 mRNA CTD PMID:25450479 sulpiride increases expression ISO RGD:68353 6480464 Sulpiride results in increased expression of NR5A2 mRNA CTD PMID:21427058 testosterone multiple interactions ISO RGD:68353 6480464 AR mutant form inhibits the reaction [Testosterone results in increased expression of NR5A2 mRNA] more ... CTD PMID:21273442 testosterone increases expression ISO RGD:68353 6480464 Testosterone results in increased expression of NR5A2 mRNA CTD PMID:21273442 tetrachloromethane decreases expression ISO RGD:68353 6480464 Carbon Tetrachloride results in decreased expression of NR5A2 mRNA CTD PMID:31150632 titanium dioxide multiple interactions ISO RGD:68500 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NR5A2 mRNA CTD PMID:29950665 trichloroethene multiple interactions ISO RGD:68500 6480464 PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of NR5A2 mRNA] CTD PMID:15363585 ursodeoxycholic acid increases expression ISO RGD:68500 6480464 Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA CTD PMID:18687751 ursodeoxycholic acid multiple interactions ISO RGD:68500 6480464 NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA] CTD PMID:18687751 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of NR5A2 mRNA CTD PMID:24935251 vancomycin multiple interactions ISO RGD:68500 6480464 [Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA CTD PMID:24657338 vincristine increases expression EXP 6480464 Vincristine results in increased expression of NR5A2 mRNA CTD PMID:23649840
Biological Process
bile acid metabolic process IEA UniProtKB:P45448 , ensembl:ENSMUSP000000276492290271 Ensembl GO_REF:0000107 calcineurin-mediated signaling IEA UniProtKB:Q9QWM1 , ensembl:ENSRNOP000000008122290271 Ensembl GO_REF:0000107 cellular response to leukemia inhibitory factor IEA UniProtKB:P45448 , ensembl:ENSMUSP000000276492290271 Ensembl GO_REF:0000107 cholesterol homeostasis IEA UniProtKB:P45448 , ensembl:ENSMUSP000000276492290271 Ensembl GO_REF:0000107 embryo development ending in birth or egg hatching TAS 2290271 (PMID:16289203) UniProtKB PMID:16289203 epithelial cell differentiation IEA UniProtKB:P45448 , ensembl:ENSMUSP000000276492290271 Ensembl GO_REF:0000107 homeostatic process NAS 2290271 (PMID:16289203) UniProtKB PMID:16289203 hormone-mediated signaling pathway IBA FB:FBgn0001078 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 intracellular receptor signaling pathway IEA GO:0004879 2290271 GOC GO_REF:0000108 pancreas morphogenesis IEA UniProtKB:P45448 , ensembl:ENSMUSP000000276492290271 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IBA FB:FBgn0001078 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 positive regulation of transcription by RNA polymerase II ISS UniProtKB:P45448 2290271 BHF-UCL GO_REF:0000024 positive regulation of transcription, DNA-templated IDA 2290271 (PMID:15143342) BHF-UCL PMID:15143342 positive regulation of transcription, DNA-templated TAS 2290271 (PMID:15205472) BHF-UCL PMID:15205472 positive regulation of viral genome replication IDA 2290271 (PMID:19264593) BHF-UCL PMID:19264593 regulation of cell population proliferation IEA UniProtKB:P45448 , ensembl:ENSMUSP000000276492290271 Ensembl GO_REF:0000107 regulation of transcription, DNA-templated IDA 2290271 (PMID:15723037) UniProtKB PMID:15723037 regulation of transcription, DNA-templated IEA InterPro:IPR001628 more ... 2290271 InterPro GO_REF:0000002 regulation of transcription, DNA-templated TAS 2290271 (PMID:16289203) UniProtKB PMID:16289203 steroid hormone mediated signaling pathway IEA GO:0003707 2290271 GOC GO_REF:0000108 tissue development IBA MGI:MGI:1346833 , PANTHER:PTN000639680 2290271 (PMID:21873635) GO_Central PMID:21873635 transcription initiation from RNA polymerase II promoter TAS 2290271 Reactome Reactome:R-HSA-383280
Cellular Component
cytoplasm IDA 2290271 (PMID:15205472) BHF-UCL PMID:15205472 nuclear chromatin ISA tfclass:2.1.5 2290271 NTNU_SB GO_REF:0000113 nucleoplasm TAS 2290271 Reactome Reactome:R-HSA-376419 more ... nucleus IEA UniProtKB-SubCell:SL-0191 2290271 UniProtKB GO_REF:0000040 nucleus IDA 2290271 (PMID:15143342), (PMID:15205472) BHF-UCL PMID:15143342 , PMID:15205472 RNA polymerase II transcription factor complex ISS UniProtKB:P45448 2290271 BHF-UCL GO_REF:0000024 RNA polymerase II transcription factor complex IBA MGI:MGI:1346833 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635
Molecular Function
chromatin binding ISS UniProtKB:P45448 2290271 BHF-UCL GO_REF:0000024 chromatin binding IBA MGI:MGI:1346833 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 DNA binding IDA 2290271 (PMID:16289203) UniProtKB PMID:16289203 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:P45448 , ensembl:ENSMUSP000000276492290271 Ensembl GO_REF:0000107 DNA-binding transcription factor activity IEA InterPro:IPR001628 2290271 InterPro GO_REF:0000002 DNA-binding transcription factor activity IDA 2290271 (PMID:15205472), (PMID:15723037), (PMID:16289203) BHF-UCL PMID:15205472 more ... DNA-binding transcription factor activity, RNA polymerase II-specific ISM InterPro:IPR000324 more ... 2290271 (PMID:19274049) NTNU_SB PMID:19274049 DNA-binding transcription factor activity, RNA polymerase II-specific ISA tfclass:2.1.5 2290271 NTNU_SB GO_REF:0000113 nuclear receptor activity TAS 2290271 (PMID:16271724) UniProtKB PMID:16271724 nuclear receptor activity IBA FB:FBgn0261239 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 phospholipid binding IDA 2290271 (PMID:15723037) UniProtKB PMID:15723037 protein binding IPI UniProtKB:Q6STE5 2290271 (PMID:14701856) UniProtKB PMID:14701856 protein binding IPI UniProtKB:Q15466 2290271 (PMID:22504882) IntAct PMID:22504882 protein binding IPI UniProtKB:P35222 2290271 (PMID:22187462) IntAct PMID:22187462 protein binding IPI UniProtKB:Q15596 2290271 (PMID:22504882) IntAct PMID:22504882 protein binding IPI UniProtKB:Q92786 2290271 (PMID:15143342), (PMID:15205472), (PMID:19264593) BHF-UCL PMID:15143342 more ... protein binding IPI UniProtKB:O60869 2290271 (PMID:12040021) IntAct PMID:12040021 protein binding IPI UniProtKB:Q92830 2290271 (PMID:17664281) UniProtKB PMID:17664281 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS UniProtKB:P45448 2290271 BHF-UCL GO_REF:0000024 sequence-specific DNA binding IDA 2290271 (PMID:16289203) UniProtKB PMID:16289203 sequence-specific DNA binding IEA InterPro:IPR001628 2290271 InterPro GO_REF:0000002 steroid hormone receptor activity IEA InterPro:IPR001723 2290271 InterPro GO_REF:0000002 transcription regulatory region DNA binding IDA 2290271 (PMID:15205472) BHF-UCL PMID:15205472 transcription regulatory region sequence-specific DNA binding IBA FB:FBgn0001078 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 zinc ion binding IEA InterPro:IPR001628 , InterPro:IPR013088 2290271 InterPro GO_REF:0000002