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Gene: ACAN (aggrecan) Homo sapiens
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Symbol: ACAN
Name: aggrecan
Description: Predicted to have extracellular matrix structural constituent. Predicted to be involved in central nervous system development and skeletal system development. Localizes to collagen-containing extracellular matrix. Biomarker of multiple sclerosis and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGC1; AGCAN; aggrecan 1; aggrecan core protein; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1; CSPG1; CSPGCP; large aggregating proteoglycan; MSK16; SEDK; SSOAOD
Orthologs:
Mus musculus (house mouse) : Acan (aggrecan)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acan (aggrecan)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acan (aggrecan)
Pan paniscus (bonobo/pygmy chimpanzee) : ACAN (aggrecan)
Canis lupus familiaris (dog) : ACAN (aggrecan)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acan (aggrecan)
Sus scrofa (pig) : ACAN (aggrecan)
Chlorocebus sabaeus (African green monkey) : ACAN (aggrecan)
Heterocephalus glaber (naked mole-rat) : Acan (aggrecan)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1588,803,436 - 88,875,354 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl1588,803,440 - 88,875,354 (+)EnsemblGRCh38hg38GRCh38
GRCh381588,803,436 - 88,875,354 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371589,346,674 - 89,418,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,147,678 - 87,219,589 (+)NCBINCBI36hg18NCBI36
Build 341587,147,993 - 87,218,832NCBI
Celera1565,748,790 - 65,819,902 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1565,458,891 - 65,530,587 (+)NCBIHuRef
CHM1_11589,188,178 - 89,259,230 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ACAN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68507
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.