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Gene: Pttg1 (pituitary tumor-transforming gene 1) Mus musculus
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Symbol: Pttg1
Name: pituitary tumor-transforming gene 1
Description: Exhibits cysteine-type endopeptidase inhibitor activity. Involved in homologous chromosome segregation and mitotic sister chromatid cohesion. Localizes to cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; limb; mesonephric tubule of male; and primary sex cord. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (+)-dexrazoxane; 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW555095; C87862; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; Pttg; Pttg3; securin
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1143,420,250 - 43,426,251 (-)EnsemblGRCm38mm10GRCm38
GRCm381143,420,244 - 43,427,463 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371143,233,750 - 43,239,750 (-)NCBIGRCm37mm9NCBIm37
MGSCv361143,263,687 - 43,269,404 (-)NCBImm8
Celera1148,048,753 - 48,054,761 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pttg1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68512
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.